In this paper, the authors show how to implement in a simple way some complex real-life constraints on the portfolio optimization problem, so that it becomes amenable to quantum optimization algorithms. Specifically, first we explain how to obtain the best investment portfolio with a given target risk. This is important in order to produce portfolios with different risk profiles, as typically offered by financial institutions. Second, we show how to implement individual investment bands, i.e., minimum and maximum possible investments for each asset. This is also important in order to impose diversification and avoid corner solutions. Quite remarkably, we show how to build the constrained cost function as a quadratic binary optimization (QUBO) problem, this being the natural input of quantum annealers. The validity of our implementation is proven by finding the optimal portfolios, using D-Wave Hybrid and its Advantage quantum processor, on portfolios built with all the assets from S&P100 and S&P500.